Relationship between retinol binding protein 4,25-hydroxy vitamin D and lower extremity arteriald disease in type 2 diabetes mellitus patients / 中国糖尿病杂志

ABSTRACT

Objective To investigate the relationship among retinol binding protein 4(RBP-4), 25-hydroxy vitamin D [25(OH)D]concerntrations and lower extremity arterial disease (LEAD)in type 2 diabetes mellitus (T2DM) patients. Methods A total of 197 T2DM patients and 80 healthy subjects were recruited in this study.The diabetic patients were assigned to group without complications (non-LEAD)and group complicated with LEAD (LEAD).Biochemical indications,serum RBP4 and 25(OH)D concentrations were measured. Results Serum RBP4 levels in LEAD group[(39.14 ± 2.14) μg/ml] increased as compared with that in group non-LEAD [(30.01 ± 2.09)μg/ml]and NC group [(14.09 ± 1.88)μg/ml](P<0.01).Serum 25(OH)D concentrations in LEAD group [(11.63 ± 6.83)ng/ml]were lower than that in Non-LEAD group [(18.02 ± 6.42)ng/ml]and NC group[(23.39 ± 4.68)ng/ml](P<0.05).Serum RBP-4 was positively associated with triglycerides (TG),low density lipoprotein cholesterol (LDL-C),homeostasis model assessment for insulin resistance (HOMA-IR),body mass index (BMI), waist-hip ratio (WHR)and negatively associated with 25(OH)D and high density lipoprotein cholesterol (HDL-C).Serum 25(OH)D had a negative correlation with RBP-4,HbA1c,fasting plasma glucose(FPG),HOMA-IR and duration.Logistic regression analysis showed that HDL-C and 25(OH)D were protective factors of LEAD. Conclusion Increased serum RBP-4 levels and reduced 25(OH)D concentrations are significantly associated with the occurrence of LEAD in patients with T 2DM.