Investigation for Peripheral Blood Levels of Erythrocyte Micro-particles in Patients With Acute Coronary Syndrome / 中国循环杂志

ABSTRACT

Objective: To assess the clinical significance of peripheral blood levels of erythrocyte micro-particles on acute coronary syndrome (ACS) diagnosis. Methods: A total of 150 patients treated in our hospital from 2015-01 to 2016-09 were enrolled in this study. The patients were divided into 2 groups Non-CAD (coronary artery disease) group, n=45 and ACS group, n=105. ACS group was further divided into 3 subgroups STEMI (acute ST-segment elevation myocardial infarction) subgroup, n=37, Non-STEMI subgroup, n=31 and UAP (Unstable angina pectoris) subgroup, n=37. Peripheral blood sample was collected, erythrocyte micro-particles were separated by Ca2+ vector A23187 method and relevant micro-particles were labeled by specific antibody (glycophorine A) for qualitative and quantitative flow cytometry analysis. Results: Compared with Non-CAD group, ACS group had the higher peripheral level of erythrocyte micro-particles [％, 26.20 (15.90, 38.00) vs 14.00 (4.35, 36.35), P<0.05]. In ACS group, erythrocyte micro-particles were similar among 3 subgroups in STEMI subgroup [％, 27.20 (17.25, 24.25)], in Non-STEMI subgroup [％, 21.50 (12.76, 34.90)] and in UAP subgroup [％, 30.20 (17.10, 39.65)], P>0.05. Conclusion: Peripheral blood levels of erythrocyte micro-particles were elevated in ACS patients which implied it may involve ACS development and could be related to acute thrombosis event in ACS patients.