Differential expression of lncRNAs in patients with depression and its relationship with personality traits and social support / 中华行为医学与脑科学杂志

ABSTRACT

Objective To explore the differential expression of lncRNAs in patients with depression and its relationship with personality traits and social support.Methods The differential expression of lncRNAs in 5 patients with depression (MDD) and 5 normal controls (NC) was screened by gene chip.To validate the gene chip dataset,qRT-PCR was used to verify the expression levels of these 10 lncRNAs in a separate set of 138 consecutive patients and 43 normal subjects,and then the relationships of lncRNA expression level with personality traits and social support were analyzed.Results A total of 2 649 lncRNAs were differentially expressed,of which 534 were up-regulated and 2 115 down-regulated.The expression levels of 8 lncRNAs analyzed by qRT-PCR in patients with depression were significantly down-regulated (P＜0.05 or P＜0.01).The △Ct value of PY4 was negatively correlated with anxiety/somatization factor (r=-0.210,P＜0.05),and the △Ct values of PY1,PY2 and PY6 were negatively correlated with the social support availability (r=-0.383,-0.391,-0.381 all P＜0.05).Apart from PY1,the △Ct values of the other lncRNAs were negatively correlated with paranoid (P＜0.05),the △Ct values of PY3,PY6 and PY9 were negatively correlated with the borderline and obsessive-compulsive (P＜0.05) and except for PY10,the △Ct values of the other lncRNAs were negatively correlated with the schizoid (P＜0.05).Conclusion The expression levels of theses 8 lncRNAs are significantly down-regulated in patients with depression,and there is a certain correlation with anxiety/somatization factor,personality traits and social support.