Peripheral inflammatory markers in the patients with mild cognitive impairment:a meta-analysis / 中华行为医学与脑科学杂志

ABSTRACT

Objective To evaluate the association of peripheral blood inflammatory cytokines with mild cognitive impairment ( MCI) . Methods Databases including Pubmed,Cochrane library,Ovid,Web of science,CNKI,CBM,VIP and Wan Fang were retrieved to collect case-control studies related to the concen-tration of inflammatory cytokines in peripheral blood of MCI. After extracting data and appraising the quality of the included studies,meta-analysis were conducted using RevMan 5. 3 and CMA 3. 0. Results The lev-els of CRP,TNF-α,IL-1,MCP-1 and M-CSF and other 9 kinds of inflammatory factors in 33 studies were in-cluded in the analysis. A total of 8742 subjects were enrolled,including 2398 patients and 6344 controls. The Meta-analysis showed that the levels of CRP (SMD=0. 87,95％CI (0. 48,1. 26),P<0. 0001),TNF-α(SMD=1. 16,95％CI (0. 32,2. 00),P=0. 007),IL-1β (SMD=0. 96,95％CI (0. 17,1. 76),P=0. 02),IL-6 (SMD=1. 07, 95％CI (0. 53,1. 61),P<0. 0001),IL-8 (SMD=1. 65,95％CI (0. 36,2. 93),P=0. 01) in peripheral blood of pa-tients with MCI were significantly higher than that of normal control group;however,there was no statistical differ-ence between the two groups in the levels of IL-10,IL-12,MCP-1 and M-CSF. Conclusion The patients with MCI has a higher levels of CRP,TNF-α,IL-1β,IL-6 and IL-8 in peripheral blood,which suggesting that these in-flammatory factors may be related to the occurrence and development of AD.