Analgesic Effect of 0.1% Pranoprofen Eyedrops in Refractive Surgery

ABSTRACT

We evaluated the effect of 0.1% Pranoprofen,a non-steroidal antiinflammatory drug, and therapeutic contact lens in the pain control after refractive surgeries.One hundred and two patients undergone PRK were subdivided into 4 groups 27 patients treated with placebo (Group 1), 28 patients with Pranoprofen (Group 2), 30 patients with therapeutic contactlens (Group 3) and 17 patients with Pranoprofen and contact lens (Group 4). Forty-seven patients undergone LASIK were subdivided into 2 groups 27 patients treated with placebo (Group 5) and 20 patients with Pranoprofen (Group 6). We recorded and analyzed visual analogue scale, 6 questions about pain and pain scores during postoperative 48 hours to evaluate the degree of pain. In PRK groups, analgesic effect was evident in groups using Pranoprofen (Group 2,4) compared to the groups not using the drugs (Group 1,3). The analgesic effect was augmented by the combined use of therapeutic contact lenses along with Pranoprofen (Group 4). Pranoprofen did not have an adverse effect on corneal epithelial wound healing.In LASIK groups,pain control was more effective in Pranoprofen using groups. However, it was not statistically significant. In conclusion, 0.1%Pranoprofen can be used effectively to reduce postoperative pain following PRK and LASIK procedures and the analgesic effect of the drug can be augmented by the combined use of therapeutic contact lenses.