Release characteristics in vitro and pharmacokinetics of chitosan coated curcumin liposomes in rats / 中国药理学通报

ABSTRACT

Aim To investigate the in vitro release be-havior of chitosan coated curcumin liposomes ( CMLP-CS ) and its pharmacokinetic characteristics in rats. Methods The cumulative release rate of CMLP-CS in pH 1. 2 hydrochloric acid solution and pH 6. 8 phos-phate buffer solution was investigated by dynamic dial-ysis method. The in vitro release curve was drawn. The release behavior was evaluated by similarity factor method. The drug concentration in blood was deter-mined by high performance liquid chromatography ( HPLC) . The pharmacokinetic data were analyzed by DAS 2.1.1 software. Results The cumulative release rate of CMLP-CS in pH 1. 2 hydrochloric acid solution and pH 6. 8 phosphate buffer solution was ( 70.48 ±0.50)％, (72.35 ± 1.04)％, respectively, and CM-LP-CS release in two release media was similar. AUC (0～72 h) , MRT (0～72 h) and Cmax were calculated to be 8.9, 3.7 and 1. 5 times of free curcumin, re-spectively. The relative bioavailability of CMLP-CS was 846. 5％. Conclusion CMLP-CS can improve the in vitro release behavior and significantly enhance the fraction of bioavailability of curcumin in rats.