Murine models of infectious exacerbation of respiratory disease / 中国药理学通报

ABSTRACT

Asthma, chronic obstructive pulmonary disease (COPD), cystic fibrosis(CF) lung disease are common chronic respiratory diseases. There has been evidence that respiratory in-fections with bacteria and viruses underpin the pathogenesis of the respiratory diseases. It is now well-recognized that early life infections may induce more severe asthma by inducing permanent alterations in immunity and lung structure, and even induce ster-oid-resistant severe asthma in adulthood. Respiratory infections will exacerbate the inflammation and remodeling in lung of COPD. P. aeruginosa infection in lung will induce CF. There are no effective therapies preventing or reversing the exacerbation of respiratory diseases. The development and use of mouse mod-els are proved to be valuable in understanding the role of infec-tion in disease pathogenesis. This article reviews the progresses in murine models of infectious exacerbation of respiratory disea-ses, emphasizes on the pathological changes of the three respira-tory diseases found with the application of murine models, and explores the therapeutic method which can be developed and tested by the application of murine models, in order to offer ref-erence for clinical research and treatment.