Research progress on variations of endogenous metabolites and intestinal bacteria in ulcerative colitis / 中国药理学与毒理学杂志

ABSTRACT

Ulcerative colitis(UC)is a common chronic intestinal inflammation and one of the modern diseases that are difficult to cure effectively.Increasing attention is paid on UC based on metabonomic and microbe analysis. In this article, we review the recent advances in endogenous metabolites including amino acid, energy metabolism and lipid metabolism, intestinal bacteria including Firmicutes, Bacte-roidetes, Proteobacteria and Actinobacteria as well as covariation between metabolites and intestinal bacteria in UC.Short chain fatty acid and tryptophan are used as examples to ecaborate on the important functions of metabolism of nutrients and intestinal bacteria in diseases and illustrate the contributions of intestinal bacteria to diseases.