Progress on side effects of drugs induced by aortic binding / 中国药理学与毒理学杂志

ABSTRACT

Some drugs, such as hydralazine, imidazole, muzolimine, rofecoxib, AZD5248 and ZD4407, have aortic binding character. The mechanism by which aortic binding impairs of elastin formation is analyzed here.Aortic binding research methods,such as[14C]labeled compound quantitative analysis,quantitative whole body autoradiography studies,in vitro benzaldehyde and propionic aldehyde reactivity assay and in vitro[14C]labeled compound competitive aortic tissue binding assay,are summa-rized.Studies show that aorta binding may induce side effects of drugs,which should become a health concern.