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Endpoints for evaluating drug-induced liver injury in vitro and their application in detection systems / 中国药理学与毒理学杂志
Chinese Journal of Pharmacology and Toxicology ; (6): 81-88, 2018.
Artigo em Chinês | WPRIM | ID: wpr-705245
ABSTRACT
Drug-induced liver injury (DILI) is a major cause of acute liver failure in clinic.Numerous emerging cell-based models and high-throughput screening technologies are being applied to hepato?toxicity evaluation in vitro.Before applying these emerging technologies and approaches,it is important to determine which endpoints should be included in the testing system to improve the predictive power of DILI. Based on the important mechanisms of DILI, this review introduces the endpoints that can be used for in vitro evaluation of DILI,such as hepatotoxicity,mitochondrial toxicity,cholestatic,liver injury caused by active metabolites,and immune-based liver injury.The application of these endpoints in DILI detection systems and the challenges in the application process are summarized so as to provide refer?ence for in vitro evaluation of hepatotoxicity in the early stage of new drug development.

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Tipo de estudo: Estudo diagnóstico / Estudo prognóstico Idioma: Chinês Revista: Chinese Journal of Pharmacology and Toxicology Ano de publicação: 2018 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Tipo de estudo: Estudo diagnóstico / Estudo prognóstico Idioma: Chinês Revista: Chinese Journal of Pharmacology and Toxicology Ano de publicação: 2018 Tipo de documento: Artigo