Epigenetic changes in cytochrome P450 and indirect carcinogen carcinogenesis:a review / 中国药理学与毒理学杂志
Chinese Journal of Pharmacology and Toxicology
;
(6): 150-160, 2018.
Artigo
em Chinês
| WPRIM
| ID: wpr-705254
ABSTRACT
Cytochrome P450(CYP450),one of the most important enzymes in the human body,medi?ates the activation and toxicity of indirect poisons as well as indirect carcinogens. CYP450 is a super?family mainly composed of CYP1A, CYP1B, CYP2A, CYP2B, CYP2C, CYP2E, CYP2W, CYP3A and their activities are widely modulated by epigenetic manners, such as DNA methylation, histone modifi?cation and microRNA interference.Indirect carcinogens including benzo(a)pyrene,2,3,7,8-tetrachlorod?ibenzo-p-dioxin,diethylstilbestrol,aflatoxin B1 and cyclophosphamide,can change epigenetic modifica?tions, such as specific changes in DNA methylation, histone acetylation, methylation or ubiquitination, and up-or down-regulation of microRNA expression,which affect the function of the major subtypes of CYP450 and their role in indirect carcinogen activation.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Pharmacology and Toxicology
Ano de publicação:
2018
Tipo de documento:
Artigo
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