Study on smooth wheezing effect of polysaccharide of Cydonia oblonga Mill in bronchial asthma rat / 中国药理学与毒理学杂志

ABSTRACT

OBJECTIVE Using bronchial asthma rats, to observe the effects of Smooth wheezing effect of polysaccharide. In addition, to study the effects of COM in different bronchial asthma model. METHODS Bronchial rats established by ovalbumin (OVA), were randomly divided into different group.Every other week building reference literature intraperitoneal injection of OVA, 21 d after injection of 3 consecutive ultrasonic atomization inhalation of 1% OVA stimulating 30 d,stimulate the 31 d began to medicine.Lavage for 4 weeks ELISA test ratio of IgE,SP-A,IL-4 and IL-5 was serum and bronchoal veolar lavage fluid etc.Data was in x ± s tabular format,SPSS16.0 statistics software is used to perform statistical analysis on the data, and P<0.05 shows meaningful statistical difference. RESULTS Quince polysac-charide can reduce the IgE,IL-4 level and elevated the SP-A,IL-5 level in serum and bronchoal veolar lavage fluid.CONCLUSION Quince polysaccharide has antiasthmatic effect on bronchial asthma rats.