The Role of TWIST in Ovarian Epithelial Cancers
Korean Journal of Pathology
;
: 283-291, 2014.
Artigo
em Inglês
| WPRIM
| ID: wpr-70530
ABSTRACT
BACKGROUND:
Epithelial-mesenchymal transition (EMT) is associated with tumor hypoxia. EMT is regulated, in part, by the action of TWIST, which inhibits of E-cadherin expression and may interfere with the p53 tumor-suppressor pathway.METHODS:
We examined the expression of TWIST, E-cadherin, hypoxia-inducible factor 1alpha (HIF1alpha), and p53 by immunohistochemistry in 123 cases of ovarian epithelial cancers (OEC) to evaluate the role of TWIST in OEC. We assessed the association between protein expression and clinicopathologic parameters.RESULTS:
The expression of TWIST, E-cadherin, HIF1alpha, and p53 proteins was found in 28.5%, 51.2%, 35.0%, and 29.3% of cases, respectively. TWIST expression was associated with higher histologic grade and unfavorable survival. TWIST expression was correlated with HIF1alpha expression and reduced E-cadherin expression. The altered HIF1alpha/TWIST/E-cadherin pathway was associated with lower overall survival (OS), while the co-expression of TWIST and p53 was correlated with lower progression-free survival. In the multivariate analyses, TWIST expression was an independent prognostic factor for OS.CONCLUSIONS:
Our data imply that TWIST expression could be a useful predictor of unfavorable prognosis for OEC. TWIST may affect the p53 tumor-suppressor pathway. Moreover, hypoxia-mediated EMT, which involves the HIF1alpha/TWIST/E-cadherin pathway may play an important role in the progression of OEC.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Prognóstico
/
Imuno-Histoquímica
/
Caderinas
/
Análise Multivariada
/
Proteína Supressora de Tumor p53
/
Intervalo Livre de Doença
/
Proteína 1 Relacionada a Twist
/
Transição Epitelial-Mesenquimal
/
Hipóxia
Tipo de estudo:
Estudo prognóstico
Idioma:
Inglês
Revista:
Korean Journal of Pathology
Ano de publicação:
2014
Tipo de documento:
Artigo
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