Transdermal Permeation of Compound Film Forming Gel in vitro / 中国药师
China Pharmacist
;
(12): 1993-1996, 2017.
Artigo
em Chinês
| WPRIM
| ID: wpr-705408
ABSTRACT
Objective:
To study the preparation and in vitro release and transdermal absorption of compound film forming gel.Methods:
The compound film forming gel was made from new types of film-forming materials. The in vitro release rate was determined by Franz diffusion cells.Results:
The in vitro release rate of mupirocin and dyclonine from the compound film forming gel was 81.34% and 88.46%,the transdermal cumulative release amount was(192.73 ± 0.45) μg·cm-2and(103.58 ± 0.66) μg·cm-2,and the skin retention was (419.81 ± 1.48) μg·cm-2and (212.07 ± 1.81) μg·cm-2, respectively.Conclusion:
The release of drug is nearly complete. The transdermal absorption test shows that about 30.26% mupirocin and 32.53% dyclonine can pass through skin, and about 65.91% mupirocin and 66.59% dyclonine are stored in skin. The preparation not only plays the role of bacteriostasis,but also promotes wound healing and analgesia.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
China Pharmacist
Ano de publicação:
2017
Tipo de documento:
Artigo
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