Pharmacokinetics of Erlotinib in Rats with Undernourished Status / 中国药师

ABSTRACT

Objective:To investigate the pharmacokinetics of erlotinib in SD rats with undernourished status. Methods:The ani-mal model of undernourished status was established. The rats were randomly divided into the normal control group and the undernour-ished model group. The different groups were administered with erlotinib(6.25 mg·kg-1) via tail vein,and administered with erlo-tinib (13.5 mg·kg-1) oral solution or oral suspension. The plasma concentration of erlotinib was determined by HPLC. The pharma-cokinetic parameters were calculated. Results:Compared with that of the normal control group, Tmaxin the rats with undernourished status was significantly delayed(P<0.05),while AUC0~tand AUC0~∞were without notable changes(P>0.05). As for the oral sus-pension,Tmaxwas shorter,and AUC0~tand AUC0~∞were higher in the rats with undernourished status than those in the rats with nor-mal status(P<0.05). CL in the rats with undernourished status treated with oral solution or oral suspension was 10% lower than that in the rats with normal status(P<0.05). Conclusion:Undernourished status has a significant impact on the pharmacokinetics of er-lotinib in vivo. It is suggested that the treatment regimen of erlotinib should be adjusted for the patients with undernourished status.