Change and significance of bilirubin in the patients of acute ischemic stroke with diabetes mellitus / 中国医师杂志

ABSTRACT

Objective To investigate the change and possible role of bilirubin between with and without diabetes mellitus in the population of acute ischemic stroke. Methods ⑴A total of 610 hospitali-zation patients at the Department of Neurology in Affiliated Drum Tower Hospital of Nanjing University Medi-cal School from October 2008 to September 2012, who were diagnosed as acute ischemic stroke was divided into two groups based on diabetes mellitus or not, and 138 hospitalization patients with vertigo or dizzy diag-nosed as posterior ischemic while had no acute ischemic stroke were set as a control, divided into two groups based on the same standard too. Also, serum direct bilirubin and total bilirubin and new infarction or not were recorded. ⑵The levels of direct bilirubin and total bilirubin were compared between groups of diabetes and without diabetes, whatever in the population of acute ischemic stroke or not. Results ⑴The levels of serum total bilirubin and direct bilirubin were decreased obviously in the group of diabetes mellitus compared to the group of non-diabetes mellitus in the population of acute ischemic stroke [(17. 085 ± 0. 595)μmol/L vs (18. 920 ± 0. 487)μmol/L, P=0. 024;(4. 362 ± 0. 147)μmol/L vs (4. 876 ± 0. 135)μmol/L, P =0. 019 ] . ⑵There were no obvious difference of serum total bilirubin and direct bilirubin between the groups of diabetes mellitus and non-diabetes mellitus in the population of non-ischemic stroke ( P>0. 05 ) . Con-clusions Induction of bilirubin by acute ischemic stroke can be inhibited by diabetes mellitus, which may be one of the mechanisms of deteriorative brain damage by diabetes mellitus after acute ischemic stroke.