Clinical significance of colposcopy combined with DNA quantitative analysis for cervical cancer and precancerous lesions / 中国医师杂志

ABSTRACT

Objective To explore the clinical value of DNA quantitative analysis combined with colposcopy in the diagnosis of cervical cancer and precancerous lesions.Methods From January 2015 to January 2017, 500 women with sexual history were enrolled for obstetrics and gynecology.The sensitivity, specificity, and accuracy of DNA quantitative analysis, colposcopy, and the combination of them were evaluated by the pathological examination.Results The DNA quantitative analysis showed that the sensitivity of cervical lesions was 73.75％, the specificity was 94.05％,the positive predictive value was70.24％, and the accuracy rate was 90.8％.Colposcopy showed that the sensitivity of cervical lesions was 82.5％, specificity was 91.43％, positive predictive value was 64.71％, and the accuracy rate was 90.0％.When the two were used together, the sensitivity was 87.5％, the specificity was 95.71％, and the highest accuracy was 94.4％.When three methods were compared together, the differences among the specificity and the accuracy were statistically significant (P ＜ 0.05).For any pairwise comparison, the accuracy of the combined examination was better than that of DNA quantitative analysis and colposcopy (P ＜ 0.05).The specificity of combined examination was significantly better than that of colposcopy (P ＜ 0.05).The sensitivity of combined examination was better than that of DNA quantitative analysis (P ＜ 0.05).Conclusions DNA quantitative analysis combined with colposcopy screening has a higher sensitivity, specificity and accuracy, and it has the best diagnostic value for screening of cervical cancer and precancerous lesions.