New progress in the study of IL-17 in renal diseases / 中国医师杂志

ABSTRACT

Interleukin (IL)17 is a pro-inflammatory cytokine produced by the activated CD4 + T cell subsets (Th17).It can regulate the function of cells involving in the pathogenesis of inflammation,autoimmune,neoplastic disease.The IL-17 family consists of six family members,IL-17A,IL-17B,IL-17C,IL-17D,IL-17E and IL-17F,respectively.The IL-17 receptor family consists of five members,IL-17RA,IL-17RB,IL-17RC,IL-17RD and IL-17RE,respectively.This review summarizes the characteristics and functions of the IL-17 family,the IL-17 receptor family,and the Th17/IL-17 axis.It also reviews the research about IL-17 in various kidney diseases.