Observation on macular microvascular changes in eyes of non-proliferative diabetic retinopathy patients by optical coherence tomography angiography / 中国医师杂志

ABSTRACT

Objective To observe changes in retinal microvasculature in non proliferative diabetic retinopathy (NPDR) patients by optical coherence tomography angiography (OCTA).Methods 90 eyes of 90 patients with clinical diagnosis of NPDR (DR group) by FFA who were diagnosed in Tianjin Eye Hospital from February 2016 to June 2016 and 30 control eyes of 30 age-matched healthy subjects (control group) that received imaging using OCTA.Foveal avascular zone (FAZ) size and mean vascular density of macula were evaluated.Results FAZ size of DR eyes was larger than that of control eyes (P ＜ 0.05).Macular mean vascular density of DR eyes was smaller than that of control eyes (P ＜ 0.05).Spearman's rank test demonstrated a negative correlation between DR severity and vascular density (r =-0.390,P ＜0.05),but there was no significant difference in the FAZ size between the different NPDR stages (P ＞0.05).Conclusions Vessel density of macula in the NPDR patients had superior diagnostic performance than FAZ size.OCTA is a rapid,noninvasive and effective method for early assessment of abnormal macular microcirculation in patients with NPDR.