Association of XPD Asp312Asn single nucleotide polymorphisms with oxaliplatin based chemotherapy / 中国医师杂志
Journal of Chinese Physician
; (12): 1510-1513, 2018.
Article
em Zh
| WPRIM
| ID: wpr-706024
Biblioteca responsável:
WPRO
ABSTRACT
Objective This study was to determine the role of the Xeroderma pigmentosum group D (XPD) Asp312Asn polymorphism in predicting response to Oxaliplatin based chemotherapies and survival in patients with metastatic colorectal cancer.Methods This study enrolled a total of 106 patients treated with FOLFOX4 (n =72) or XELOX (n =34) regimen.The genotype of XPD Asp312Asn was analyzed by TaqMan probe based real-Time polymerase chain reaction (PCR).Logistic regression was used to predict the response to the treatments.Cox proportion hazards models and Kaplan-Meier method were applied to predict the survival.Results The effective rate of chemotherapy in 106 patients with colorectal cancer was 57.6% (61/106).There was no significant difference in the distribution of G/G,G/A and A/A genotypes between the two groups (P > 0.05).Multivariate survival analysis showed that the survival time of patients with A/A genotype,carcinoembryonic antigen (CEA) (>5 ng/ml) and age (>65 years) was relatively short,with statistical significance (P < 0.05).Conclusions XPD Asp312Asn single nucleic acid polymorphism can be used as a predictor of survival in patients with metastatic colorectal cancer,but it is not associated with oxaliplatin sensitivity and needs further study.
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Índice:
WPRIM
Tipo de estudo:
Prognostic_studies
Idioma:
Zh
Revista:
Journal of Chinese Physician
Ano de publicação:
2018
Tipo de documento:
Article