MR first-pass myocardial perfusion imaging in evaluation of myocardial ischemia in hypertrophic cardiomyopathy / 中国医学影像技术

ABSTRACT

Objective To evaluate the myocardial ischemia in hypertrophic cardiomyopathy (HCM) patients with MR first-pass myocardial perfusion imaging.Methods Totally 20 patients with HCM (HCM group) and 10 healthy volunteers (control group) underwent cardiac MR scanning,including left ventricle short axial cine,first-pass myocardial perfusion imaging and delayed enhanced imaging.Then the left ventricular end-diastolic wall thickness (EDTH) was measured.The blood pool-signal strength curves of the near,middle and far segments of left ventricle were drawn,and then time to peak (tpeak),maximal upslope of time-intensity curve (Slopemax),peak signal intensity (SIpeak) were measured.According to EDTH,different segments of HCM were divided into non-hypertrophic subgroup and hypertrophic subgroup,and patients in hypertrophic subgroup were further divided as slightly (15-19 mm),moderately (20-24 mm) and severely hypertrophic level (25-29 mm).One-way ANOVA analysis was used to analyze the differences of tpeak,Slope SIpeak among groups,as well as every two subgroups and levels.Results The differences of Slopemax,tpeak between control group and non-hypertrophic group were not statistically significant (both P ＞ 0.05).The differences of Slopemax and tpeak between nonhypertrophic group and hypertrophic group were statistically significant (both P＜0.05).In hypertrophic subgroup,Slopemax of slightly hypertrophic level was higher than that of moderately and severely hypertrophic level (both P＜ 0.05),and tpeak of moderately hypertrophic level was higher than that of slightly hypertrophic level (P＜0.05).However,Slopemax and tpeak between moderately and severely hypertrophic level,SIpeak between every two levels were not significantly different (all P＞ 0.05).Conclusion MR first-pass myocardial perfusion imaging can reflect myocardial ischemia of different hypertrophic segments of HCM,contributing to risk stratification,therapy planning and prognosis evaluation of HCM patients.