Investigation of default mode networks in rhesus macaque brain with 7.0T resting-state fMRI / 中国医学影像技术

ABSTRACT

Objective To investigate default mode networks (DMN) in healthy rhesus monkey brain.Methods Under anesthesia,two healthy rhesus macaques underwent resting state fMRI at a 7.0T MR scanner.The functional images were firstly normalized to the standard rhesus monkey template 112SM-RL-T1,and the GIFT software was aplied to conduct group-level independent component analysis on all preprocessed functional images.Results The functional connectivity maps of the resting-state networks of rhesus macaques were obtained using this method.DMN bilaterally included posterior cingulate cortex,anterior cingulate cortex,medial parietal cortex,retrosplenial cortex,arcuate sulcus,ventral intraparietal area,temporoparietal area,superior temporal sulcus dorsal bank and a portion of visual cortex.Conclusion With the help of cutting-edge 7.0T fMRI technology,It was demonstrated that DMN of rhesus macaque brain highly resembled the ones in human,which could support the notion that non-primates are useful models for neuropharmacological and neurocognitive studies.