Detection and analysis of serum HIF-1 alpha and CG of patient with COPD in acute stage before and after treatment / 中国医学装备

ABSTRACT

Objective:To study the evaluation value of cholyglycine (CG) and hypoxia inducible factor 1 alpha (HIF-1α) in detecting patients with chronic obstructive pulmonary disease (COPD) at acute attack stage.Methods: 78 patients with COPD at acute attack stage were divided into observation group, and 78 healthy persons who were confirmed by physical examination at the same time were divided into control group. The expressions of CG and HIF-1α of the two groups were compared, and the effect and clinical value of CRP, IL-8 and LTB4 of patients in the diagnosis were evaluated.Results: In prior treatment, the concentrations of CG (11.45±1.28 mg/L) and CRP (28.68±3.63 mg/L)of observation group were significantly higher than that (2.12±0.62 mg/L, 4.89±1.27 mg/L)of control group (t=57.937, t=5.634, P<0.05), respectively. And for observation group, HIF-1α(0.76±0.22 ng/mL), IL-8(36.88±4.26 pg/mL) and LTB4 (368.26±57.29 pg/mL) of post-treatment were significantly lower than that (1.04±0.27ng/mL, 53.21±6.22pg/mL, 553.25±62.03 pg/mL) of pretreatment (t=7.100,t=19.130,t=19.349,P<0.05), respectively.Conclusion:The detections of CG and HIF-1 in the evaluation of patients with COPD has important clinical reference value, and they can provide basis for the assessment of state of illness, and the relevant diagnosis and treatment scheme.