Analysis on application value of the detections of TSP-1 and VEGF in patients with lung cancer / 中国医学装备

ABSTRACT

Objective: To investigate the application value of the detections of thrombin sensitive protein-1(TSP-1) and vascular endothelial growth factor (VEGF) in patients with lung cancer. Methods: 90 patients with lung cancer were divided into lung cancer metastasis group (47 cases) and lung cancer non-metastasis group (43 cases) according to the pathological diagnosis results, and 40 persons whose results of physical examination were healthy were selected as the control group. The levels of TSP-1 and VEGF of the three groups were observed, and Spearman analysis was used to explore the correlations between TSP-1, VEGF and lung cancer, respectively. Results: The levels of TSP-1 and VEGF of platelet-poor plasma in the three groups were lower than the detection limit of the kit. And the levels of TSP-1 in platelet of the lung cancer metastasis group and non-metastatic group were significantly lower than those of the control group (t=-11.307, t=-6.295, t=12.851, t=9.732, P<0.05). In the platelet of lung cancer metastasis group, the level of TSP-1 was significantly lower than that of lung cancer non-metastasis group (t=-5.777, P<0.05), and the level of VEGF of metastasis group was significantly higher than that of lung cancer non-metastasis group (t=4.624, P<0.05). The results of Spearman correlation analysis showed that the correlation between platelet TSP-1 and lung cancer was negative correlation (r=-0.697, P<0.05), and that between platelet VEGF and lung cancer was positively correlation (r=0.757, P<0.05). Conclusion: The changes of TSP-1 and VEGF of platelet of patients with lung cancer are significantly, which are closely related to the progress of disease of patients with lung cancer. Therefore, the judgment about diagnosis and metastasis for patients with lung cancer have certain application value.