Research progress of immunotherapy for gastric cancer / 中国肿瘤临床

ABSTRACT

Gastric cancer is one of the most common malignant tumors worldwide,and it has become the second most common tu-mor following lung cancer in China.Surgery,radiotherapy,and chemotherapy are the predominant treatments for gastric cancer.Most patients are diagnosed when they have progressed to advanced cancer,although comprehensive treatment may cure some patients with early-stage gastric cancer.With the rapid development of medical immunology and molecular biology techniques,immunothera-py as a new treatment method has received extensive attention in the field of cancer therapy.Cancer immunology involves destroying tumor cells by activating and training the patient's immune system to recognize tumor cells as targets.This is the goal of tumor thera-py.Immunotherapeutic methods now include adoptive T-cell transfer,novel antibody constructs,cytokines,and cancer vaccines.In the last decade,researchers have obtained encouraging results in the field of cancer immunotherapy,especially with the use of check-point inhibitors.This article reviews the advances in immunotherapy for gastric cancer.