Research progress of epithelial-to-mesenchymal(-like) transition in glioblastoma / 中国肿瘤临床

ABSTRACT

Epithelial-to-mesenchymal transition (EMT) is a normal process of cell physiological development in which the epithelial cells transform into mesenchymal cells through a specific program. EMT plays key roles in embryogenesis, tissue regeneration, and tu-mor progression. Recent research has shown the involvement of EMT-like in the tumorigenesis and progression (especially invasion and metastasis) of glioblastoma (GBM). This article reviews the molecular regulatory mechanisms of EMT (-like) including the main sig-naling pathways, EMT-factors, miRNA, cancer stem cells, hypoxia microenvironments, and therapy resistance in GBM.