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Research progress of epithelial-to-mesenchymal(-like) transition in glioblastoma / 中国肿瘤临床
Chinese Journal of Clinical Oncology ; (24): 643-647, 2018.
Artigo em Chinês | WPRIM | ID: wpr-706865
ABSTRACT
Epithelial-to-mesenchymal transition (EMT) is a normal process of cell physiological development in which the epithelial cells transform into mesenchymal cells through a specific program. EMT plays key roles in embryogenesis, tissue regeneration, and tu-mor progression. Recent research has shown the involvement of EMT-like in the tumorigenesis and progression (especially invasion and metastasis) of glioblastoma (GBM). This article reviews the molecular regulatory mechanisms of EMT (-like) including the main sig-naling pathways, EMT-factors, miRNA, cancer stem cells, hypoxia microenvironments, and therapy resistance in GBM.

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Chinese Journal of Clinical Oncology Ano de publicação: 2018 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Chinese Journal of Clinical Oncology Ano de publicação: 2018 Tipo de documento: Artigo