Expression and significance of NAD (P) H: quinone oxidoreductase 1 and heme oxygen-ase-1 proteins in T-cell lymphoma / 中国肿瘤临床
Chinese Journal of Clinical Oncology
;
(24): 1033-1037, 2018.
Artigo
em Chinês
| WPRIM
| ID: wpr-706877
ABSTRACT
Objective:
To investigate the expression of NAD (P) H quinone oxidoreductase 1 (NQO1) and heme oxygenase-1 (HO-1) in T-cell lymphoma (TCL), and investigate the correlation between these two indicators and other clinicopathological parameters in TCL.Methods:
Clinical data of 61 patients with TCL who were initially diagnosed in Gansu Provincial Hospital were analyzed retrospectively. Immunohistochemical examination was performed to detect NQO1 and HO-1 expression levels in 61 TCL tissues (TCL group) and 20 lymph node reactive hyperplasia tissues (control group).Results:
Positive expression rates of NQO1 and HO-1 were significantly higher in TCL tissues than in lymph node reactive hyperplasia tissues (P<0.05). NQO1 expression was closely related with Ann-Arbor clinical stage and B symptoms (P<0.05); HO-1 expression was correlated with clinical stage, bone marrow invasion, and B symptoms (P<0.05). NQO1 and HO-1 expression levels were not related to age, sex, lactate dehydrogenase level, and pathological type (P>0.05); there was a correlation between NQO1 and HO-1 expression (r=0.264; P=0.040).Conclusions:
NQO1 and HO-1 are highly expressed in TCL and may interact and contribute to the occurrence and development of TCL.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Journal of Clinical Oncology
Ano de publicação:
2018
Tipo de documento:
Artigo
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