Clinical significances of JAK2 mutation in patients with polycythemia vera / 中国肿瘤临床
Chinese Journal of Clinical Oncology
;
(24): 1109-1112, 2018.
Artigo
em Chinês
| WPRIM
| ID: wpr-706892
ABSTRACT
Polycythemia vera (PV) is a myeloproliferative neoplasm (MPN) characterized by overproduction of red blood cells. The pathogenesis of PV is not completely understood. However, studies report that it may be associated with the gain-of-function somatic mutation of JAK2 and that the JAK2 mutation provides a molecular diagnostic standard for PV. JAK2 mutation and allele mutation bur-den are useful for predicting clinical features and courses. The discovery of JAK2 mutation has promoted the development of molecu-lar-targeted therapy, such as the JAK2 inhibitor, ruxolitinib, a drug with superior therapeutic effect and safety that is used in clinical practice. The JAK2 allele mutation burden is closely associated with leukocytosis and progression to myelofibrosis (MF). A high JAK2 al-lele mutation burden may be a risk factor for poor prognosis. This article briefly reviews the clinical significance of the JAK2 mutation in patients with PV.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo prognóstico
Idioma:
Chinês
Revista:
Chinese Journal of Clinical Oncology
Ano de publicação:
2018
Tipo de documento:
Artigo
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