Study on pathogenesis and traditional Chinese medicine syndrome differentiation of acute lung injury / 中国中西医结合急救杂志

ABSTRACT

Acute lung injury (ALI) and its evoked acute respiratory distress syndrome (ARDS) are the main causes of acute respiratory failure (ARF) in many clinical severe diseases, so that ALI is one of the clinical serious respiratory diseases. The mortality of ALI is persisting at high level without any lowering. And its basic pathological manifestations often show injury of pulmonary capillary membrane caused by uncontrolled inflammation, pulmonary edema and formation of transparent membrane. In this article, from the point of view of inflammation, oxidation stress, cell apoptosis, autophagy, etc to comprehensively summarize the pathogenesis of ALI, explaining the relationships between the occurrence of ALI and the uncontrolled inflammation, cytokines release, the unbalance of oxidation and anti-oxidation system, and different inducing factors leading to cellular autophagy. Moreover, the general research situation of traditional Chinese medicine and Chinese herbal compound prescription for treatment of ALI was summarized. According to the TCM theory of "lung and the large intestine being interior-exteriorly related", the TCM method of Xuanfeitongfu method was proposed to be used for prevention and treatment of ALI, and from the point of view of inflammatory reaction regulation and autophagy pathway, the theoretical connotation was revealed, aiming to provide a direction for basic research and development of new traditional Chinese medicine for treatment of ALI.