Study on application of Supportan in elderly bedridden patients with enteral nutrition support / 中国中西医结合急救杂志

ABSTRACT

Objective To explore the application value of Supportan in elderly bedridden patients with enteral nutrition (EN) support. Methods Forty cases of elderly bedridden patients admitted to the Department of Intensive Care Unit (ICU) of Hangzhou First People's Hospital from January 2015 to January 2016 were enrolled, Supportan was injected through an indwelling naso-intestinal tube on the basis of routine treatment, and the changes of blood biochemical parameters of EN [serum albumin (Alb), pre-albumin (PA), total lymphocyte count (LYM)] and immune indexes (IgG, IgM, IgA) were monitored before and after EN treatment. Results Ten days after EN treatment, the serum Alb, PA, LYM, IgG, IgM were significantly higher than those before treatment, the differences being statistically significant [Alb (g/L) 30.29±1.65 vs. 28.31±1.72, PA (g/L) 0.25±0.05 vs. 0.23±0.02, LYM (×109) 1.69±0.28 vs. 1.47±0.32, IgG (g/L) 11.54±0.96 vs. 10.69±0.70, IgM (g/L) 1.21±0.19 vs. 0.95±0.13, all P < 0.05]; 20 days after EN treatment, above indexes were increased more significantly compared with those 10 days after EN treatment [Alb (g/L) 34.16±2.41 vs. 30.29±1.65, PA (g/L) 0.28±0.03 vs. 0.25±0.05, LYM (×109/L) 1.96±0.31 vs. 1.69±0.28, IgG (g/L) 14.56±0.77 vs. 11.54±0.96, IgM (g/L) 1.56±0.18 vs. 1.21±0.19, all P < 0.05], 10 days, 20 days after EN treatment, IgA shown a tendency increased, there was no statistical significant difference compared with that before treatment (g/L 2.63±0.33, 2.67±0.11 vs. 2.61±0.27, both P > 0.05). Conclusion Supportan has important clinical significance in improving the nutritional status and immune function of elderly bedridden patients.