Malignant Solitary Fibrous Tumor of the Pleura in Mediastinum
Korean Journal of Pathology
;
: 351-356, 1997.
Artigo
em Coreano
| WPRIM
| ID: wpr-7090
ABSTRACT
Solitary fibrous tumors (SFTs) most often involve the pleura and also may encompass the peritoneum and nonserosal sites. They occur as solitary encapsulated tumors and pursue a relatively benign clinical course. The usual criteria for malignancy are high cellularity, mitotic activity (more than 4 per 10 high-power fields), cellular pleomorphism, hemorrhage and necrosis as well as infiltrative growth. We report a case of malignant SFT of pleura who presented with an anterior mediastinal mass. Grossly, it was a 10x8x6.5 cm sized, encapsulated and well-demarcated, solid neoplasm with areas of extensive necrosis. Microscopically, parallel or haphazard arrangement of spindle cells with variable degrees of collagenous background were noted. Storiform fascicle formation, hemangiopericytoma-like pattern, and epithelioid cell clusters were often intermingled. Nodular areas with high cellularity and mitotic activity (> or =10/10 HPFs) were scattered throughout the neoplasm, however no definite cellular pleomorphism was encountered. Tumor cells were immunoreactive for vimentin and CD-34, which distinguished them from the mesothelial cells. Electron microscopically, they revealed fibroblastic and myofibroblastic differentiation.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Peritônio
/
Pleura
/
Vimentina
/
Células Epitelioides
/
Colágeno
/
Tumores Fibrosos Solitários
/
Tumor Fibroso Solitário Pleural
/
Miofibroblastos
/
Fibroblastos
/
Hemorragia
Idioma:
Coreano
Revista:
Korean Journal of Pathology
Ano de publicação:
1997
Tipo de documento:
Artigo
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