New methods and strategies to improve functional cure rate of chronic hepatitis B / 中华临床感染病杂志

ABSTRACT

Chronic hepatitis B ( CHB), characterized by recurrent liver inflammation caused by hepatitis B virus(HBV), can further develop into decompensated liver cirrhosis ,liver cancer or liver failure. The currently used therapeutic drugs nucleos ( t) ide analogues and interferon can effectively inhibit virus replication, but it is difficult to achieve functional cure ( clinical cure) because of their inability to destroy covalently closed ring DNA ( cccDNA).So we are still facing problems of low HBsAg clearance rate and high recurrence rate after drug withdraw.In recent years, the emerging of new drugs and biological agents provide novel ideas and directions for the functional cure of CHB.This article briefly reviews the new therapeutic methods and strategies for functional cure of CHB.