Relationship of clinical and radiological characteristics with pathogenesis of acute small deep cerebellar infarction / 中华老年心脑血管病杂志

ABSTRACT

Objective To study the relationship of clinical and radiological characteristics with the pathogenesis of acute small deep cerebellar infarction (SDCI).Methods Ninety-five patients with acute small cerebellar infarction admitted to our hospital from April 2015 to April 2017 were divided into deep cerebellar infarction (DCI) group (n =20) and cortical infarction group (n =75).Their clinical and imaging characteristics were compared.Results The lacunar infarction score,leukoararaiosis score and microbleeds score were significantly higher [2 (1,2)score vs 1 (0,1) score,P=0.001;3(2,4)score vs 1(1,2)score,P=0.000;30.0％ vs 6.7％,P=0.041] while the incidence of AF and carotid or basilar artery atheromatous sclerosis was significantly lower (5.0％ vs 30.7 ％,P =0.040;15.0 ％ vs 40.0 ％,P =0.037;20.0 ％ vs 60.0 ％,P =0.001),the incidence of small artery lesions was significantly higher while that of atherosclerotic and cardiogenic throm bosis was significantly lower in DCI group than in cortical infarction group (P＜0.05,P＜0.01).Multivariate logistic regression analysis showed that lacunar cerebellar infarction and cerebral microbleeds were the independent risk factors for DCI (OR=3.233,95％CI1.538-6.795,P=0.002;OR=8.123,95％CI2.182-5.301,P=0.009) and that DCI was positively related with small artery lesions (OR=5.481,95％CI1.811-19.815,P=0.006).Conclusion SDCI is induced by small vessel lesions.