Relationship of HbAlc rate and serum fibrinogen level with cognitive impairment in acute ischemic stroke patients / 中华老年心脑血管病杂志

ABSTRACT

Objective To analyze the relationship of HbAlc rate and serum fibrinogen (Fib) level with cognitive impairment in acute ischemic stroke (AIS) patients.Methods One hundred and sixty AIS patients admitted to our hospital were divided into control group (n=80) with a MoCA score ≥26 and cognitive impairment group (n=80) with a MoCA score ＜26.Their HbA1c rate and serum Fib level were measured within 24 h after admission and their cognitive function was assessed according to the MoCA score on days 7-10 after admission.Results The HbA1c rate and serum Fib level were significantly higher in cognitive impairment group than in control group (6.98％±1.02％ vs 5.12％±0.54％,3.65±0.54 g/L vs 2.12±0.46 g/L,P＜0.01).The scores of MoCA,visual space and executive performance,language,attention and calculation,abstract thinking,delayed memory,and orientation were significantly lower in cognitive impairment group than in control group (P＜0.01).Correlation analysis showed that HbA1c rate and serum Fib level,visual space and executive performance,language,attention and calculation,delayed memory were negatively related with the total MoCA score (P＜0.01).Conclusion HbA1c rate and serum Fib level are closely related with cognitive impairment in AIS patients and are thus the risk factors for cognitive impairment.