Sodium-glucose cotransport 2 inhibitors ameliorate the "metabolic stress" / 中华内分泌代谢杂志

ABSTRACT

Energy intake excess in modern society contributes to the abrupt increase of type 2 diabetes. The sodium-glucose cotransport 2 (SGLT-2) inhibitors, a new class of hypoglycemic agents inhibit reabsorption of glucose and excrete excessive energy by the kidney and therefore ameliorate the metabolic stress. The relief of metabolic stress further improves blood glucose, lipid levels, so as blood pressure, insulin resistance and pancreatic β cell function, which would be associated with the protection of cardiovascular diseases and amelioration of renal function.