Effects of lipid accumulation index on islet β-cell function in middle-aged and elderly population / 中华内分泌代谢杂志
Chinese Journal of Endocrinology and Metabolism
; (12): 228-232, 2018.
Article
em Zh
| WPRIM
| ID: wpr-709930
Biblioteca responsável:
WPRO
ABSTRACT
To investigate the effect of lipid accumulation index on islet βcell function in middle-aged and elderly people.A total of 10 109 subjects were enrolled in the community residents of Dalian City,aged≥40 years, from July to December 2011, according to enrollment and exclusion criteria.The relationship between lipid accumulation index(LAP)and homeostasis model assessment for βcell function(HOMA-β)was described by curve fitting model, and the effect of LAP on HOMA-βwas proved by correlation and linear regression analysis.The relationship between LAP and HOMA-βshowed an inverted U trend.With the increase of LAP,HOMA-βincreased gradually, following then entered the plateau, and then decreased slowly.According to the LAP quartile classification,each category was analyzed separately as a separate data.Spearman correlation results showed that HOMA-βwas positively correlated with LAP in Q1 group, not in Q2 and Q3 group, while in Q4 group, it was negatively correlated.Multivariate linear regression analysis showed that LAP could enter the equation in group Q1 and group Q4 after adjustment of age, sex, systolic blood pressure, diastolic blood pressure, low density lipoprotein-cholesterol,and high density lipoprotein-cholesterol(all P<0.05).With the increase of LAP,pancreatic β-cell secretion activity increases compensatorily,then decreases to decompensation and finally to the process of weakening secretion.
Texto completo:
1
Índice:
WPRIM
Tipo de estudo:
Prognostic_studies
Idioma:
Zh
Revista:
Chinese Journal of Endocrinology and Metabolism
Ano de publicação:
2018
Tipo de documento:
Article