Pharmacokinetic behaviors of four constituents in Huanglian Xiangru Decoction in rat plasma / 中成药

ABSTRACT

AIM To investigate the pharmacokinetic behaviors of four constituents in Huanglian Xiangru Decoction in rat plasma.METHODS The rats intragastrically administered with diluted drug (9 g/kg) had their blood collected for the determination of plasma concentration by HPLC,after which pharmacokinetic parameters were calculated by 3p97 software.RESULTS The plasma concentration-time curves for berberine hydrochloride,apigenin,honokiol,magnolol accorded with open one compartment model,with the Tpeak values of (1.436 5 ± 0.311 9),(2.049 5 ±0.705 5),(1.359 0 ±0.343 4),(1.195 9 ±0.334 6) h,AUC values of (1.477 8 ± 0.4840),(1.063 0±0.452 1),(0.863 5±0.2697),(7.0105 ±2.584 7) μg/(mL· h),Cmax values of (0.245 9 ±0.019 4),(0.129 6 ±0.016 7),(0.180 9 ±0.021 3),(0.966 7 ±0.042 0) μg/mL,respectively.CONCLUSION Compared with the other three constituents in Huanglian Xiangru Decoction,magnolol demonstrates better in vivo absorption and higher bioavailability.