Thrombelastography in evaluating effect of antiplatelet drugs for patients undergoing peripheral endovascular treatment and relationship with ischemic-events-free duration / 中华普通外科杂志
Chinese Journal of General Surgery
;
(12): 126-129, 2018.
Artigo
em Chinês
| WPRIM
| ID: wpr-710509
ABSTRACT
Objective To evaluate the effect of antiplatelet drugs and ischemic-events-free duration by thromboelastography (TEG) in patients undergoing peripheral endovascular treatment.Methods From Mar 2015 to Oct 2016,38 patients undergoing initial successful peripheral stenting and then coming back for recurrent ischemic events.TEG was used to evaluate the platelet inhibition rate induced by arachidonic acid (AA%) approach,the platelet inhibition rate induced by adenosine diphosphate (ADP%) approach,and the ADP-induced platelet-fibrin clot strength (MAADP).Clinical feature differences between patients with MAADP > 47 mm and MAADP ≤ 47 mm were compared.Results AA% less than 50% was found in 9 patients(23.9%),and ADP% less than 30% in 14 patients(36.8%).5 patients met the two conditions.Patients with MAADp > 47 mm had a significantly lower ADP% (x2 =10.755,P < 0.001),compared to patients with MAADP ≤47 mm.Univariate survival analysis showed ADP% < 30% and MAADP >47 mm were risk factors for getting shorter ischemic-events-free duration,compared to patients with ADP% ≥ 30 (P < 0.001),with MAADP ≤47 mm (x2 =4.408,P =0.036).Conclusions TEG may detect those patients who has a low response to antiplatelet drugs,and some TEG parameters may have a ischemic predictive value.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo prognóstico
/
Fatores de risco
Idioma:
Chinês
Revista:
Chinese Journal of General Surgery
Ano de publicação:
2018
Tipo de documento:
Artigo
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