Progress in innate lymphoid cells in intestinal homeostasis and diseases / 中华微生物学和免疫学杂志

ABSTRACT

Innate lymphoid cells are the most recently discovered family of lymphocytes and a group of innate immune cells. They cannot directly participate in specific immune responses due to lack of pattern recognition and recombination receptors. According to the transcription factors that regulate their de-velopment and function and the cytokines that they can produce, ILCs can be divided into three groups:ILC1, ILC2 and ILC3. ILC1 and ILC3 also include several different subtypes. ILCs play an important role in maintaining the integrity of intestinal mucosal epithelium, regulating intestinal microbiote, promoting the de-velopment of the intestinal immune system and regulating intestinal inflammation. This article reviews the roles of ILCs in intestinal homeostasis maintenance and the development of intestinal diseases.