Application value of haptoglobin as bile and serum biomarkers for biliary tract carcinoma / 中华消化内镜杂志
Chinese Journal of Digestive Endoscopy
;
(12): 171-174, 2018.
Artigo
em Chinês
| WPRIM
| ID: wpr-711501
ABSTRACT
Objective To detect cancer-related biomarkers for early diagnosis of biliary tract carcinoma. Methods Bile and serums were obtained from patients with histopathologically proven malignant or benign biliary diseases, and clinical data of patients were recorded. Two-dimensional liquid chromatography tandem mass spectrometry(2D-LC-MS/MS)was applied to detect the differential protein profiles in the bile. Western blot was used to validate the results in the biles and serums. Results Ten differential protein profiles were detected in 4 protein groups. Among them, the expression of haptoglobin significantly increased in the bile of patients with malignancy. This result was further verified using Western blot. Conclusion Haptoglobin may be a potential biomarker for biliary tract carcinoma.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo de rastreamento
Idioma:
Chinês
Revista:
Chinese Journal of Digestive Endoscopy
Ano de publicação:
2018
Tipo de documento:
Artigo
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