Isomer specificity of conjugated linoleic acid (CLA): 9E,11E-CLA
Nutrition Research and Practice
;
: 326-330, 2008.
Artigo
em Inglês
| WPRIM
| ID: wpr-71162
ABSTRACT
Conjugated linoleic acids (CLA) were identified in 1980's, since then it has been intensively studied due to its various beneficial health effects such as anti-inflammatory, anti-atherogenic, anti-carcinogenic and anti-diabetic/obesity effects. Isomer specificity of a number of CLA isomers, especially predominant isomer 9Z,11E- and 10E,12Z-CLA, is now recognized. However, the less prevalent CLA isomers have not been well characterized. Recently, studies have reported the distinctively different effects of 9E,11E-CLA in colon cancer cells, endothelial cells, and macrophage cells compared to the rest of CLA isomers. In this review, various effects of CLAs, especially anti-inflammatory and anti-atherogenic effects, will be discussed with focusing on the isomer-specific effects and potential mechanism of action of CLA. At last, recent studies about 9E,11E-CLA in in vitro and animal models will be discussed.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Sensibilidade e Especificidade
/
Neoplasias do Colo
/
Ácido Linoleico
/
Modelos Animais
/
Células Endoteliais
/
Ácidos Linoleicos Conjugados
/
Macrófagos
Tipo de estudo:
Estudo diagnóstico
Idioma:
Inglês
Revista:
Nutrition Research and Practice
Ano de publicação:
2008
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS