Effects of carotid shear rate on carotid intima-media thickness in kidney transplant recipients / 中华医学超声杂志（电子版）

ABSTRACT

Objective To analyze the relation between carotid intima-media thickness (IMT) and the shear rate (SR),and to explore the effect of SR on IMT in the patients with end-stage renal disease (ESRD)and the kidney transplant recipients (KTR).Methods From March 2014 to December 2015,31 KTR and 31 patients with ESRD supported by hemodialysis and 84 control subjects underwent an carotid ultrasound in Shanghai General Hospital affiliated to Shanghai Jiaotong University.Bilateral carotid IMT and SR were measured.The differences of IMT and SR in three groups were compared by single factor analysis of variance.SNK-q test was used to compare the two groups.The correlation between SR and bilateral IMT was analyzed by linear regression analysis in healthy control group,ESRD group and KTR group.Results On the right,in ESRD,KTR and control group,the IMTs were (561.9± 147.7) μm,(480.5±90.3) μtm and (529.7±131.80) μtm respectively.Compared with KTR and control group,the IMT on right was thickest in ESRD,but there was no significant difference between KTR and control group in right IMT.On the left,the IMTs were (517.5± 164.7) μm,(506.7± 126.3) μm and (467.0± 106.4) μm in control group,ESRD and KTR,respectively.Among groups,there was no significant difference.On the right,the SRs were (134.01 ±56.4) s-1,(133.4±43.7) s-1 and (175.8±68.3) s-1 in ESRD,KTR and control group,respectively.In ESRD and KTR groups,the SR of the right carotid artery was less than that of the control group,and had significant difference (q=3.133,P=0.002;q=3.470,P ＜ 0.001).There was no significant difference in right SR between ESRD and KTR.On the left,the SRs were (146.3±55.9) s-1,(138.5±43.8) s-1 and (154.7±60.8) s-1 in ESRD,KTR and control group,respectively,and had no significant difference.There was linear negative correlation between SR and IMT in healthy control group,ESRD group and KTR group,respectively (rightr=-0.384,-0.082,-0.454;leftr=-0.572,0.223,-0.276,all P ＜ 0.05).Conclusions The IMT was thickened in ESRD group,but got thinning after successful kidney transplantation.The SR played a vital role in this alteration of IMT.