Clinical value of bone turnover markers in the management of osteoporosis / 中华检验医学杂志

ABSTRACT

Bone turnover is balanced with coupling of bone formation and resorption at various rates leading to continuous remodeling of bone.Osteoporosis diagnosis, which is nowadays generally made based on bone mineral density(BMD)measurements, suffers from certain limitations.Bone turnover markers (BTMs)can help improve osteoporosis detection.BTMs can provide information that is useful for the management of patients with osteoporosis,for assessing the possible causes of secondary osteoporosis and the correct dosage;they are also potentially useful as surrogate biomarkers for fracture.(Chin J Lab Med,2018, 41333-336)