Research advance in Enterobacteria ceaebacteria resistant to polymyxins / 中华检验医学杂志

ABSTRACT

In order to deal with the increasing number of multidrug resistant Enterobacteriaceae , polymyxins were re-introduced into clinical practice .The resistance of polymyxins had gained global attention.In addition to chromosomal mediated drug resistance , a new plasmid-mediated colistin-resistance gene mcr-1 made transferation of polymyxins resistance more easily .Here, the mechanisms of chromosome mediated polymyxin resistance and plasmide-mediated drug resistance , including the distribution , prevalence, transfer mechanism, and genetic environments of mcr-1, current methods for polymyxins susceptibility testing methods and novel qualitative detection techniques were reviewed to provide information to cope with the growing problem of bacterial drug resistance .