Progress of tumor-derived exosomal microRNA in tumors / 肿瘤研究与临床

ABSTRACT

Exosomes are vesicular globules with physiological functions, such as intercellular material transportation and signal transduction. They can be secreted by many kinds of cells, with 40 to 100 nm diameters.Exosomes have biological properties of derived cells based on the nucleic acids, proteins and lipids in them. Tumor cells can also secrete large number of exosomes with many microRNAs (miRNAs), and miRNAs from different maternal tumor cells are different. This paper mainly reviews the early diagnosis of tumors by tumor-derived exosomal miRNAs and the relationship between miRNAs and tumorigenesis and tumor progression.