Progress of long non-coding RNA in colorectal cancer / 肿瘤研究与临床

ABSTRACT

Colorectal cancer is one of the most familiar malignant neoplasms,but the pathogenesis of colorectal cancer is not clear now.Recently the studies show that the long non-coding RNA(lncRNA)plays a regulatory role in various systemic tumors,including colorectal cancer.LncRNA is a non-coding RNA over 200 nucleotides.Five types of lncRNA including H19,colorectal cancer-associated transcript 1(CCAT1),HOX transcriptional antisense RNA(HOTAIR),lung adenocarcinoma-associated transcription factor 1(MALAT1),maternal imprinted expression gene 3(MEG3)are closely related to colorectal cancer.They are well correlated with the occurrence,development,clinical staging,overall survival,and prognosis of colorectal cancer.Therefore,lncRNA is expected to be a new marker for the diagnosis and evaluation of colorectal cancer in clinical work.