In Vitro Release of Vancomycin from Vancomycin-loaded Demineralized Bone Coated with Hematoma / 대한정형외과연구학회지
Journal of Korean Orthopaedic Research Society
;
: 55-60, 2002.
Artigo
em Coreano
| WPRIM
| ID: wpr-71296
ABSTRACT
PURPOSE:
This study was performed to find a method to utilize demineralized bone matrix as a vehicle for local delivery of the antibiotics for the treatment of chronic osteomyelitis. MATERIALS ANDMETHODS:
Bovine bone blocks with the same size were randomly divided into 4 groups. Using Demineralization and hematoma coating, the different characteristics were given to each group, and Vancomycin was adsorbed to these bone blocks. We performed two identical experiments with Phosphate-buffered Saline and Fetal Bovine Serum as a solute. We exchange the solution with 24-hour interval for 6 weeks. The eluted concentrations of Vancomycin at each week were measured.RESULTS:
Regardless of the solution used, the eluted concentration of Vancomycin was significantly higher in demineralized and hematoma-coated group than those of other groups. The eluted concentration of Vancomycin were 22.6ng/ml at week 6 in saline condition and 12.4ng/ml at week 5 in serum condition.CONCLUSIONS:
We thought that demineralized and hematoma-coated cancellous bone can be used as a good vehicle for local antibiotics delivery.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Osteomielite
/
Matriz Óssea
/
Vancomicina
/
Hematoma
/
Antibacterianos
Idioma:
Coreano
Revista:
Journal of Korean Orthopaedic Research Society
Ano de publicação:
2002
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS