System-Wide Expression and Function of Olfactory Receptors in Mammals
Genomics & Informatics
; : 2-9, 2018.
Article
em En
| WPRIM
| ID: wpr-713226
Biblioteca responsável:
WPRO
ABSTRACT
Olfactory receptors (ORs) in mammals are generally considered to function as chemosensors in the olfactory organs of animals. They are membrane proteins that traverse the cytoplasmic membrane seven times and work generally by coupling to heterotrimeric G protein. The OR is a G protein–coupled receptor that binds the guanine nucleotide-binding G(αolf) subunit and the Gβγ dimer to recognize a wide spectrum of organic compounds in accordance with its cognate ligand. Mammalian ORs were originally identified from the olfactory epithelium of rat. However, it has been recently reported that the expression of ORs is not limited to the olfactory organ. In recent decades, they have been found to be expressed in diverse organs or tissues and even tumors in mammals. In this review, the expression and expected function of olfactory receptors that exist throughout an organism's system are discussed.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Membrana Celular
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Mucosa Olfatória
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Proteínas de Ligação ao GTP
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Expressão Ectópica do Gene
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Guanina
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Mamíferos
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Proteínas de Membrana
Limite:
Animals
Idioma:
En
Revista:
Genomics & Informatics
Ano de publicação:
2018
Tipo de documento:
Article