Enhanced Tendon-to-Bone Healing of Chronic Rotator Cuff Tears by Bone Marrow Aspirate Concentrate in a Rabbit Model
Clinics in Orthopedic Surgery
;
: 99-110, 2018.
Artigo
em Inglês
| WPRIM
| ID: wpr-713320
ABSTRACT
BACKGROUND:
To evaluate the influence of bone marrow aspirate concentrate (BMAC) on tendon-to-bone healing in a rabbit rotator cuff model and to characterize the composition of growth factors in BMAC.METHODS:
In this in vivo study, 40 rabbits were allocated into five groups control (C), repair + saline (RS), repair + platelet-rich plasma (PRP; RP), repair + BMAC (RB) and repair + PRP + BMAC (RPB). A tear model was created by supraspinatus tendon transection at the footprint. Six weeks after transection, the torn tendon was repaired along with BMAC or PRP administration. Six weeks after repair, shoulder samples were harvested for biomechanical and histological testing. Ten rabbits were used for processing PRP and BMAC, followed by analysis of blood cell composition and the levels of growth factors in vitro.RESULTS:
The ultimate load-to-failure was significantly higher in RPB group compared to RS group (p = 0.025). BMAC-treated groups showed higher values of biomechanical properties than RS group. The histology of BMAC-treated samples showed better collagen fiber continuity and orientation than RS group. BMAC contained significantly higher levels of the several growth factors than PRP.CONCLUSIONS:
Locally administered BMAC enhanced tendon-to-bone healing and has potential for clinical applications.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Ombro
/
Lágrimas
/
Tendões
/
Células Sanguíneas
/
Medula Óssea
/
Técnicas In Vitro
/
Colágeno
/
Manguito Rotador
/
Peptídeos e Proteínas de Sinalização Intercelular
/
Plasma Rico em Plaquetas
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Inglês
Revista:
Clinics in Orthopedic Surgery
Ano de publicação:
2018
Tipo de documento:
Artigo
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