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Clinical Evaluation of QMAC-dRAST for Direct and Rapid Antimicrobial Susceptibility Test with Gram-Positive Cocci from Positive Blood Culture Bottles / 대한임상미생물학회지
Annals of Clinical Microbiology ; : 12-19, 2018.
Artigo em Inglês | WPRIM | ID: wpr-713358
ABSTRACT

BACKGROUND:

Timely intervention in the treatment of bloodstream infection is important for prescription of appropriate antimicrobials. With prompt determination of the antimicrobial susceptibility of a causative agent, rapid antimicrobial susceptibility test (AST) can help select the appropriate antimicrobial therapy. This clinical study is for evaluation of the clinical performance of the QMAC-dRAST for rapid AST directly from positive blood culture (PBC)s with Gram-positive cocci.

METHODS:

A total of 115 PBC samples with Gram-positive organisms (76 Staphylococcus spp. and 39 Enterococcus spp.) were evaluated by the QMAC-dRAST system, and their pure culture isolates were evaluated by the MicroScan WalkAway (Beckman Coulter, USA) as the comparative AST system. Thirteen antimicrobial agents were included, and the agreement and discrepancy rates of the QMAC-dRAST system (Quantamatrix Inc., Republic of Korea) compared to the MicroScan WalkAway were calculated. To resolve discrepancies, the broth microdilution method was performed.

RESULTS:

The QMAC-dRAST system exhibited a categorical agreement rate of 94.9% (1,126/1,187) and an essential agreement rate of 98.3% (1,167/1,187). The QMAC-dRAST system yielded very major (false-susceptible) errors at 1.0% (5/485), major (false-resistant) errors at 1.3% (9/693), and minor errors at 4.0% (47/1,187) compared to the MicroScan WalkAway. The QMAC-dRAST system significantly eliminated 30 hours of total turnaround time by combination of direct inoculation of PBC and an image-based approach.

CONCLUSION:

The results of the QMAC-dRAST system were highly accurate. Thereby, the QMAC-dRAST may provide essential information to accelerate therapeutic decisions for earlier and adequate antibiotic treatment and patient management in clinical settings.
Assuntos

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Staphylococcus / Resistência Microbiana a Medicamentos / Testes de Sensibilidade Microbiana / Enterococcus / Bacteriemia / Cocos Gram-Positivos / Prescrições / Bioengenharia / Estudo Clínico / Métodos Tipo de estudo: Estudo prognóstico Limite: Humanos Idioma: Inglês Revista: Annals of Clinical Microbiology Ano de publicação: 2018 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Assunto principal: Staphylococcus / Resistência Microbiana a Medicamentos / Testes de Sensibilidade Microbiana / Enterococcus / Bacteriemia / Cocos Gram-Positivos / Prescrições / Bioengenharia / Estudo Clínico / Métodos Tipo de estudo: Estudo prognóstico Limite: Humanos Idioma: Inglês Revista: Annals of Clinical Microbiology Ano de publicação: 2018 Tipo de documento: Artigo